COVID 19

Hydroxychloroquine: blocks toll-like receptors (TLRs) on dendritic cells (WBC) to treat inflammatory diseases such as lupus and arthritis.

• Zinc and chloroquine (as ionophore) to block RNA-dependent RNA polymerase

• Chloroquine & Hydroxychloroquine: alkaline proton pump inhibitor. Disrupts malarial plasmodium (in food vacuole) & viruses (in lysosome, prevent fusion with endosome)

  Rheumatological/autoimmune conditions (lupus and arthritis):

  • neutrophil movement
  • eosinophil chemotaxis
• Remdesivir: inhibits RNA dependent RNA polymerase by acting as Adenosine nucleoside analog. (Similar to AZT inhibiting reverse transcriptase of HIV)

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